Revange Nutrition Happy Bee 60 caps

Noopept (omberacetam)

Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, omberacetam) is a synthetic compound described as an active pharmaceutical ingredient with nootropic activity¹.

Phenylpiracetam (fonturacetam)

Phenylpiracetam (fonturacetam) is a racetam drug related to piracetam, used as a prescription medicine in Russia.

DMHA (2-aminoisoheptane, octodrine) and DMBA

DMHA, also labelled 2-aminoisoheptane or octodrine (2-amino-6-methylheptane), is a synthetic aliphatic amine stimulant found in pre-workout and weight-loss supplements, sometimes alongside the related compound DMBA².

5-HTP (5-hydroxytryptophan)

5-HTP is the direct precursor of the neurotransmitter serotonin and is usually extracted from Griffonia simplicifolia seeds³.

Ashwagandha (Withania somnifera)

Ashwagandha (Withania somnifera) is an Ayurvedic herb marketed as an adaptogen; extracts are standardised to withanolides.

Choline (choline bitartrate, alpha-GPC)

Choline is an essential nutrient used to make cell membranes and the neurotransmitter acetylcholine. EFSA set an adequate intake of 400 mg a day for adults⁴. Supplements supply it as choline bitartrate, alpha-GPC or citicoline.

Bacopa monnieri (brahmi)

Bacopa monnieri (brahmi) is an Ayurvedic herb whose extracts contain bacosides.

Rhodiola rosea

Rhodiola rosea is a plant from cold regions whose root extract (standardised to rosavins and salidroside) is marketed as an adaptogen.

Piperine (black pepper extract, BioPerine®)

Piperine is the pungent alkaloid of black pepper, added to supplements as a "bioavailability enhancer".

Noopept (omberacetam)

There are no robust controlled trials in healthy people showing improved memory or focus. Published research is mainly chemical, animal or from limited clinical settings¹.

Phenylpiracetam (fonturacetam)

There are no robust controlled trials in healthy people showing cognitive benefits.

DMHA (2-aminoisoheptane, octodrine) and DMBA

There are no controlled human trials showing that DMHA improves exercise performance or weight loss.

5-HTP (5-hydroxytryptophan)

A review of controlled trials examined 5-HTP for depression; the evidence is limited and of mixed quality³. There is no authorised EU claim for 5-HTP.

Ashwagandha (Withania somnifera)

A 2026 meta-analysis found that current evidence does not establish that ashwagandha meaningfully enhances resistance-training adaptations; possible benefits for maximal strength rest on a small, low-certainty evidence base⁵.

Choline (choline bitartrate, alpha-GPC)

The EU authorises claims that choline contributes to normal lipid metabolism, homocysteine metabolism and liver function for foods that are a source of choline⁶. Claims that choline improves focus or exercise performance are not authorised.

Bacopa monnieri (brahmi)

A 2026 network meta-analysis found that bacopa, particularly at high doses, shows promise as a cognitive enhancer compared with ginkgo in healthy adults, although the lack of direct comparisons limits the strength of the evidence⁷.

Rhodiola rosea

A 2025 meta-analysis concluded that Rhodiola supplementation can improve endurance performance and related biomarkers, although differences between studies call for cautious interpretation⁸.

Piperine (black pepper extract, BioPerine®)

A 2026 review of 22 human pharmacokinetic studies found that reports of enhanced nutrient absorption come mainly from manufacturer-affiliated studies, and that independent trials did not confirm enhancement for curcumin or resveratrol at supplement doses⁹.

Noopept (omberacetam)

Evidence in humans is very limited.

Phenylpiracetam (fonturacetam)

Evidence is limited and mostly from Russian clinical literature.

DMHA (2-aminoisoheptane, octodrine) and DMBA

The research concerns detection of these stimulants in supplements, not their effects. Analyses of sports and weight-loss supplements have repeatedly found stimulants that were not declared, or quantities different from the label²¹⁰.

5-HTP (5-hydroxytryptophan)

Most trials are small and old³.

Ashwagandha (Withania somnifera)

Trials are small, short and often funded by extract manufacturers⁵.

Choline (choline bitartrate, alpha-GPC)

Evidence on cognitive or performance effects in healthy adults is limited.

Bacopa monnieri (brahmi)

Effects build up over weeks, and studies are small⁷.

Rhodiola rosea

Studies are heterogeneous in extract and dose⁸.

Piperine (black pepper extract, BioPerine®)

Piperine raises blood levels of other compounds mainly by inhibiting drug-metabolising enzymes (CYP3A4, CYP2C9) and P-glycoprotein, not by improving absorption⁹.

Noopept (omberacetam)

Human safety data are limited. Official medicines control laboratories in Europe and Australia have found illicit "smart drugs" sold as nootropic products and warn of their dangers¹¹.

Phenylpiracetam (fonturacetam)

Reported effects include insomnia and agitation. Official medicines control laboratories in Europe and Australia have found illicit "smart drugs" sold as nootropic products and warn of their dangers¹¹.

DMHA (2-aminoisoheptane, octodrine) and DMBA

Human safety data are lacking. As a sympathomimetic amine, DMHA may raise heart rate and blood pressure; avoid combining it with other stimulants. Contaminated supplements have caused positive doping tests¹⁰.

5-HTP (5-hydroxytryptophan)

Safety concerns include serotonin syndrome when combined with antidepressants or other serotonergic substances, and historical reports of eosinophilia-myalgia syndrome linked to contaminated products³. Do not combine with antidepressants, migraine triptans or tramadol.

Ashwagandha (Withania somnifera)

Case series describe ashwagandha-associated liver injury, which can be severe in people with existing liver disease¹². It may also affect thyroid hormones and is not recommended in pregnancy.

Choline (choline bitartrate, alpha-GPC)

High intakes can cause a fishy body odour, sweating and digestive upset.

Bacopa monnieri (brahmi)

It can cause digestive upset and may interact with thyroid and sedative medicines.

Rhodiola rosea

Generally well tolerated; it may interact with antidepressants and blood-pressure or diabetes medicines.

Piperine (black pepper extract, BioPerine®)

Because it inhibits drug-metabolising enzymes, piperine can raise blood levels of prescription medicines, including drugs with a narrow therapeutic index. People taking medication should ask a pharmacist first⁹.

Contains a synthetic research compound that is not authorised as food (novel food) or as a medicinal product in the EU. Contains DMHA/DMBA, a synthetic stimulant that is not authorised as a novel food in the EU. No dosing information for human use is provided.

Noopept (omberacetam)

Noopept is not authorised as a food or food supplement ingredient in the EU¹³. Substances with a pharmacological action on the nervous system are regulated as medicinal products in the EU, and Noopept is not an authorised medicine¹⁴.

Phenylpiracetam (fonturacetam)

Phenylpiracetam is not authorised as a food or food supplement ingredient in the EU¹³. Substances with a pharmacological action on the nervous system are regulated as medicinal products in the EU, and Phenylpiracetam is not an authorised medicine¹⁴. It is prohibited in competition by the World Anti-Doping Agency as a stimulant¹⁵.

DMHA (2-aminoisoheptane, octodrine) and DMBA

DMHA and DMBA are not authorised as novel foods in the EU¹³. Octodrine and related stimulants are prohibited in competition by the World Anti-Doping Agency¹⁰¹⁵.

5-HTP (5-hydroxytryptophan)

5-HTP is pharmacologically active; some EU Member States restrict it in food supplements or classify it as medicinal¹⁴. No health claim for this ingredient is authorised in the EU⁶; botanical ingredients are sold under national food-supplement rules¹⁶.

Ashwagandha (Withania somnifera)

No health claim for this ingredient is authorised in the EU⁶; botanical ingredients are sold under national food-supplement rules¹⁶.

Choline (choline bitartrate, alpha-GPC)

Choline is a permitted nutrient source in EU food supplements¹⁶⁶.

Bacopa monnieri (brahmi)

No health claim for this ingredient is authorised in the EU⁶; it is sold under national food-supplement rules¹⁶.

Rhodiola rosea

No health claim is authorised⁶.

Piperine (black pepper extract, BioPerine®)

No health claim for this ingredient is authorised in the EU⁶; botanical ingredients are sold under national food-supplement rules¹⁶.