Revange Nutrition Noopept RX Pro

Noopept (omberacetam)

Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, omberacetam) is a synthetic compound described as an active pharmaceutical ingredient with nootropic activity¹.

Choline (choline bitartrate, alpha-GPC)

Choline is an essential nutrient used to make cell membranes and the neurotransmitter acetylcholine. EFSA set an adequate intake of 400 mg a day for adults². Supplements supply it as choline bitartrate, alpha-GPC or citicoline.

Bacopa monnieri (brahmi)

Bacopa monnieri (brahmi) is an Ayurvedic herb whose extracts contain bacosides.

Rhodiola rosea

Rhodiola rosea is a plant from cold regions whose root extract (standardised to rosavins and salidroside) is marketed as an adaptogen.

Ashwagandha (Withania somnifera)

Ashwagandha (Withania somnifera) is an Ayurvedic herb marketed as an adaptogen; extracts are standardised to withanolides.

5-HTP (5-hydroxytryptophan)

5-HTP is the direct precursor of the neurotransmitter serotonin and is usually extracted from Griffonia simplicifolia seeds³.

L-theanine

L-theanine is an amino acid found in tea leaves, often combined with caffeine.

Phosphatidylserine, lecithin and phospholipids

Phosphatidylserine and other phospholipids are components of cell membranes. Lecithin is a mixture of phospholipids, often from sunflower or soy.

Huperzine A

Huperzine A is an alkaloid from the club moss Huperzia serrata. It inhibits acetylcholinesterase, the enzyme that breaks down the neurotransmitter acetylcholine, and it has been used as a medicine for dementia in China⁴.

L-tyrosine

L-tyrosine is an amino acid that the body uses to make the neurotransmitters dopamine and noradrenaline. It is found in protein-rich foods; N-acetyl-L-tyrosine is a related form⁵.

Noopept (omberacetam)

There are no robust controlled trials in healthy people showing improved memory or focus. Published research is mainly chemical, animal or from limited clinical settings¹.

Choline (choline bitartrate, alpha-GPC)

The EU authorises claims that choline contributes to normal lipid metabolism, homocysteine metabolism and liver function for foods that are a source of choline⁶. Claims that choline improves focus or exercise performance are not authorised.

Bacopa monnieri (brahmi)

A 2026 network meta-analysis found that bacopa, particularly at high doses, shows promise as a cognitive enhancer compared with ginkgo in healthy adults, although the lack of direct comparisons limits the strength of the evidence⁷.

Rhodiola rosea

A 2025 meta-analysis concluded that Rhodiola supplementation can improve endurance performance and related biomarkers, although differences between studies call for cautious interpretation⁸.

Ashwagandha (Withania somnifera)

A 2026 meta-analysis found that current evidence does not establish that ashwagandha meaningfully enhances resistance-training adaptations; possible benefits for maximal strength rest on a small, low-certainty evidence base⁹.

5-HTP (5-hydroxytryptophan)

A review of controlled trials examined 5-HTP for depression; the evidence is limited and of mixed quality³. There is no authorised EU claim for 5-HTP.

L-theanine

A meta-analysis of randomised trials in healthy people found that theanine with caffeine, and theanine alone, could benefit cognitive and mood outcomes¹⁰.

Phosphatidylserine, lecithin and phospholipids

A 2026 systematic review concluded that current evidence does not support citicoline or phosphatidylserine compounds as effective cognitive enhancers in mental disorders¹¹.

Huperzine A

A Cochrane review found some benefit on cognitive function in people with Alzheimer's disease, but only one study was of adequate quality and size, so there was inadequate evidence to recommend its use⁴. A Cochrane review in mild cognitive impairment found the evidence insufficient¹².

There is no good evidence that huperzine A improves focus or performance in healthy people.

L-tyrosine

A review found that tyrosine may support cognitive performance in short-term stressful or cognitively demanding situations, when these neurotransmitters are temporarily depleted, but found no consistent effect on physical exercise performance⁵.

Noopept (omberacetam)

Evidence in humans is very limited.

Choline (choline bitartrate, alpha-GPC)

Evidence on cognitive or performance effects in healthy adults is limited.

Bacopa monnieri (brahmi)

Effects build up over weeks, and studies are small⁷.

Rhodiola rosea

Studies are heterogeneous in extract and dose⁸.

Ashwagandha (Withania somnifera)

Trials are small, short and often funded by extract manufacturers⁹.

5-HTP (5-hydroxytryptophan)

Most trials are small and old³.

L-theanine

More research with realistic doses and in everyday settings is needed¹⁰.

Phosphatidylserine, lecithin and phospholipids

Studies have methodological limitations and a high risk of bias¹¹.

Huperzine A

The trials are mostly small, of limited quality and in people with cognitive disease, so they do not apply to healthy users⁴¹².

L-tyrosine

Most studies are small and use single doses in laboratory settings⁵.

Noopept (omberacetam)

Human safety data are limited. Official medicines control laboratories in Europe and Australia have found illicit "smart drugs" sold as nootropic products and warn of their dangers¹³.

Choline (choline bitartrate, alpha-GPC)

High intakes can cause a fishy body odour, sweating and digestive upset.

Bacopa monnieri (brahmi)

It can cause digestive upset and may interact with thyroid and sedative medicines.

Rhodiola rosea

Generally well tolerated; it may interact with antidepressants and blood-pressure or diabetes medicines.

Ashwagandha (Withania somnifera)

Case series describe ashwagandha-associated liver injury, which can be severe in people with existing liver disease¹⁴. It may also affect thyroid hormones and is not recommended in pregnancy.

5-HTP (5-hydroxytryptophan)

Safety concerns include serotonin syndrome when combined with antidepressants or other serotonergic substances, and historical reports of eosinophilia-myalgia syndrome linked to contaminated products³. Do not combine with antidepressants, migraine triptans or tramadol.

L-theanine

Generally well tolerated at studied doses.

Phosphatidylserine, lecithin and phospholipids

Generally well tolerated; soy lecithin may not be suitable for people with soy allergy.

Huperzine A

As an acetylcholinesterase inhibitor, huperzine A can cause nausea, diarrhoea, sweating and a slow heart rate, and it may interact with medicines that affect acetylcholine or heart rate. Anyone taking medication or with heart, lung or digestive conditions should ask a doctor first.

L-tyrosine

People taking MAO inhibitors or thyroid medication should not use tyrosine supplements without medical advice.

Flagged for compliance review: this product is listed as a food supplement in our catalogue, but its EU status (food supplement, novel food or medicinal product) has not been verified. No benefits or health claims are made.

Noopept (omberacetam)

Noopept is not authorised as a food or food supplement ingredient in the EU¹⁵. Substances with a pharmacological action on the nervous system are regulated as medicinal products in the EU, and Noopept is not an authorised medicine¹⁶.

Choline (choline bitartrate, alpha-GPC)

Choline is a permitted nutrient source in EU food supplements¹⁷⁶.

Bacopa monnieri (brahmi)

No health claim for this ingredient is authorised in the EU⁶; it is sold under national food-supplement rules¹⁷.

Rhodiola rosea

No health claim is authorised⁶.

Ashwagandha (Withania somnifera)

No health claim for this ingredient is authorised in the EU⁶; botanical ingredients are sold under national food-supplement rules¹⁷.

5-HTP (5-hydroxytryptophan)

5-HTP is pharmacologically active; some EU Member States restrict it in food supplements or classify it as medicinal¹⁶. No health claim for this ingredient is authorised in the EU⁶; botanical ingredients are sold under national food-supplement rules¹⁷.

L-theanine

No health claim for this ingredient is authorised in the EU⁶; botanical ingredients are sold under national food-supplement rules¹⁷.

Phosphatidylserine, lecithin and phospholipids

No health claim for this ingredient is authorised in the EU⁶; it is sold under national food-supplement rules¹⁷.

Huperzine A

Huperzine A is a pharmacologically active substance. Its status as a food ingredient is not harmonised in the EU, and some Member States treat it as a medicinal substance¹⁶¹⁵.

L-tyrosine

Amino acids such as L-tyrosine are used in EU food supplements under national rules. No health claim is authorised⁶.