SARMs Bulking Stack (MK 677 + RAD140)

RAD-140 (testolone)

RAD-140 (testolone) is a selective androgen receptor modulator (SARM): a synthetic, non-steroidal compound designed to activate androgen receptors in muscle and bone while having less effect on other tissues. It was developed as an investigational drug¹.

MK-677 (ibutamoren)

MK-677 (ibutamoren) is an orally active growth hormone secretagogue: it mimics the hormone ghrelin and stimulates the release of growth hormone and IGF-1. It is often grouped with SARMs but works through a different mechanism².

RAD-140 (testolone)

Preclinical studies in animals showed anabolic effects on muscle¹. The only published human trial is a phase 1 study in women with advanced, hormone-receptor-positive breast cancer, which assessed safety and dosing in that disease; it was not a study of muscle or performance in healthy people³.

A systematic review of randomised trials of SARMs in general found positive effects on physical performance and body composition in the trials reviewed, with moderate rates of mild to moderate adverse effects⁴.

MK-677 (ibutamoren)

In a 12-month randomised trial in healthy older adults, MK-677 increased growth hormone secretion and fat-free mass and was generally well tolerated².

In a phase IIb trial in older patients recovering from hip fracture, IGF-1 levels rose but most measures of physical function did not improve, and the authors concluded that MK-677 had an unfavourable safety profile in that population, including congestive heart failure in a limited number of patients⁵.

RAD-140 (testolone)

There are no controlled trials of RAD-140 in healthy people, so its effects and risks at the amounts used outside research are unknown. Analyses of products sold online as SARMs found that many did not contain what the label stated, or contained other unapproved substances⁶.

MK-677 (ibutamoren)

The trials were in older adults under medical supervision. There are no controlled studies in healthy young people or athletes. Analyses of products sold online as SARMs found that many did not contain the substance or amount stated on the label, and some contained other unapproved drugs⁶.

RAD-140 (testolone)

Case reports describe drug-induced liver injury, including jaundice, in people using products containing RAD-140⁷. A national case series linked SARMs and other bodybuilding products to drug-induced liver injury⁸.

A systematic review of SARM use by athletes reports liver toxicity, heart toxicity, tendon damage, suppression of natural testosterone and other androgenic effects⁹.

MK-677 (ibutamoren)

Reported effects in trials include increased appetite, fluid retention and raised blood glucose; heart failure occurred in a small number of frail older patients²⁵.

Contains a selective androgen receptor modulator (SARM). SARMs are investigational substances that are not authorised as medicinal products or as food (including food supplements) in the EU and are on the World Anti-Doping Agency (WADA) Prohibited List. Contains an investigational growth-hormone secretagogue. It is not authorised as a medicinal product or as food (including food supplements) in the EU and is on the WADA Prohibited List. No dosing information for human use is provided.

RAD-140 (testolone)

RAD-140 is not an approved medicine and is not permitted in food or food supplements in the EU¹⁰¹¹. SARMs have been on the World Anti-Doping Agency Prohibited List since 2008 and are prohibited at all times¹²¹³.

MK-677 (ibutamoren)

MK-677 is not an approved medicine and is not permitted in food or food supplements in the EU¹⁰¹¹. Growth hormone secretagogues are prohibited at all times by the World Anti-Doping Agency¹³.