Product guide · Food supplement
Smart Brothers Smart Agmatine 100 caps
Agmatine capsules from Smart Brothers, 100 capsules. This guide sets out what the manufacturer states about the composition of Smart Brothers Smart Agmatine 100 caps, what independent research says about its main ingredients, and the safety and regulatory points that apply.
Back to the product- Named ingredients
- 2
- Amounts stated
- All
- Status
- Food supplement
- Evidence summaries
- 2
Overview
Manufacturer informationIngredients & composition
Manufacturer information| Ingredient | Amount |
|---|---|
| Agmatine sulfate | 1000 mg |
| Arginine nitrate (NO3-T®) | 500 mg |
Scientific background
Independent researchAgmatine sulfate
Agmatine is formed in the body from the amino acid arginine and acts as a signalling molecule in the nervous system. It is sold as agmatine sulfate in sports and nootropic products.
L-arginine and AAKG
L-arginine is an amino acid used by the body to make nitric oxide. AAKG is arginine bound to alpha-ketoglutarate.
Research evidence
Independent researchAgmatine sulfate
Controlled human research on agmatine for exercise performance is very limited. Published human data are mostly small studies and a long-term case report1.
L-arginine and AAKG
A dose-response meta-analysis of randomised trials found that L-arginine lowered blood pressure in adults2. Evidence for improved exercise performance or "pump" is inconsistent; oral arginine is extensively broken down before reaching the circulation, which is why citrulline is often preferred3.
Evidence limitations
Independent researchThe studies summarised in this guide examined single ingredients. No published study has tested this product or this combination of ingredients.
Agmatine sulfate
There are no large randomised trials showing a performance benefit from agmatine in healthy people. Claims of better "pump" or focus are not established.
L-arginine and AAKG
Studies vary in dose and population2.
Safety & potential risks
- Do not exceed the recommended daily dose.
- Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
- Keep out of the reach of young children.
Agmatine sulfate
A case report described 5 years of high daily agmatine intake without detected adverse effects1. One case report cannot establish safety for the wider population.
Regulatory status
Sold as a food supplement. No health claims are made for this product.
Scientific references
- Gilad GM, Gilad VH. Long-term (5 years), high daily dosage of dietary agmatine: evidence of safety: a case report. J Med Food. 2014;17:1256-1259. PubMed 25247837
- Shiraseb F, Asbaghi O, Bagheri R, et al. Effect of L-arginine supplementation on blood pressure in adults: a systematic review and dose-response meta-analysis of randomized clinical trials. Adv Nutr. 2022;13:1226-1242. PubMed 34967840
- Gonzalez AM, Trexler ET. Effects of citrulline supplementation on exercise performance in humans: a review of the current literature. J Strength Cond Res. 2020;34:1480-1495. PubMed 31977835
- Shao A, Hathcock JN. Risk assessment for the amino acids taurine, L-glutamine and L-arginine. Regul Toxicol Pharmacol. 2008;50:376-399. PubMed 18325648
- Commission Regulation (EU) No 432/2012 establishing a list of permitted health claims made on foods. Official Journal of the European Union. Source
- Regulation (EU) 2015/2283 on novel foods. Official Journal of the European Union. Source
- Directive 2002/46/EC on the approximation of the laws of the Member States relating to food supplements. Official Journal of the European Union. Source
Sources checked against PubMed, Crossref or the official publisher on 2026-11-04. Manufacturer information is taken from the product's own data and has not been independently tested.
The product
Smart Brothers Smart Agmatine 100 caps
€23,00