Product guide · Restricted substance
Core Labs LX GH PRO ULTRA 60 caps
Research compound from Core Labs, 60 capsules. This guide sets out what the manufacturer states about the composition of Core Labs LX GH PRO ULTRA 60 caps, what independent research says about its main ingredients, and the safety and regulatory points that apply. It contains substances that are not authorised as food or medicine in the EU. This guide is educational: it does not recommend use and gives no directions for use.
Back to the product- Named ingredients
- 6
- Amounts stated
- None
- Status
- Restricted substance
- Evidence summaries
- 6
Overview
Manufacturer informationIngredients & composition
Manufacturer information| Ingredient | Amount |
|---|---|
| RAD-140 (Testolone) | Not stated |
| LGD-4033 (Ligandrol) | Not stated |
| YK-11 | Not stated |
| MK-677 (Ibutamoren) | Not stated |
| Epistane | Not stated |
| Laxosterone (5α-hydroxy-laxogenin) | Not stated |
The manufacturer does not state the amount of any ingredient. Without amounts, the research summarised in this guide cannot be related to this product's dose.
Scientific background
Independent researchRAD-140 (testolone)
RAD-140 (testolone) is a selective androgen receptor modulator (SARM): a synthetic, non-steroidal compound designed to activate androgen receptors in muscle and bone while having less effect on other tissues. It was developed as an investigational drug1.
LGD-4033 (ligandrol)
LGD-4033 (ligandrol) is a non-steroidal selective androgen receptor modulator developed as an investigational drug for muscle wasting2.
YK-11
YK-11 is a steroidal compound marketed as a SARM. In cell studies it acted as a partial androgen receptor agonist and increased follistatin, a protein that inhibits myostatin3.
MK-677 (ibutamoren)
MK-677 (ibutamoren) is an orally active growth hormone secretagogue: it mimics the hormone ghrelin and stimulates the release of growth hormone and IGF-1. It is often grouped with SARMs but works through a different mechanism4.
Prohormones and designer anabolic steroids
Prohormones and "designer steroids" are synthetic anabolic-androgenic steroids, or precursors converted to them in the body, sold in supplement-style products. Examples include methasterone ("Superdrol"), methylepitiostanol ("Epistane") and trendione ("Trenavar").
Plant "anabolic" sterols (laxogenin, ecdysterone)
Laxogenin (5α-hydroxy-laxogenin) and ecdysteroids such as ecdysterone (20-hydroxyecdysone, from Ajuga turkestanica or Cyanotis) are plant sterols marketed as natural anabolic agents.
Research evidence
Independent researchRAD-140 (testolone)
Preclinical studies in animals showed anabolic effects on muscle1. The only published human trial is a phase 1 study in women with advanced, hormone-receptor-positive breast cancer, which assessed safety and dosing in that disease; it was not a study of muscle or performance in healthy people5.
A systematic review of randomised trials of SARMs in general found positive effects on physical performance and body composition in the trials reviewed, with moderate rates of mild to moderate adverse effects6.
LGD-4033 (ligandrol)
In a 21-day randomised, placebo-controlled trial in 76 healthy young men, LGD-4033 increased lean body mass. It also caused dose-dependent suppression of total testosterone, sex hormone-binding globulin, HDL ("good") cholesterol and triglycerides2.
A systematic review of randomised SARM trials reports positive effects on body composition and physical performance with moderate rates of mild to moderate adverse effects6.
YK-11
The evidence is limited to cell and animal studies; a rodent study raised concerns about effects on the hippocampus, a brain region involved in memory37. There are no published human trials.
MK-677 (ibutamoren)
In a 12-month randomised trial in healthy older adults, MK-677 increased growth hormone secretion and fat-free mass and was generally well tolerated4.
In a phase IIb trial in older patients recovering from hip fracture, IGF-1 levels rose but most measures of physical function did not improve, and the authors concluded that MK-677 had an unfavourable safety profile in that population, including congestive heart failure in a limited number of patients8.
Prohormones and designer anabolic steroids
No controlled trials support the safety of these products. Their muscle-building effect derives from anabolic-androgenic steroid activity, the same mechanism as controlled steroid drugs.
Plant "anabolic" sterols (laxogenin, ecdysterone)
In a 12-week randomised double-blind training study, a commercial ecdysterone product gave no additional benefit over training alone, and its actual content differed markedly from the label9. In castrated rats, 5α-hydroxy-laxogenin showed neither androgenic nor anabolic effects10.
Evidence limitations
Independent researchThis product does not state all ingredient amounts, so the doses used in research cannot be compared with what one serving provides.
The studies summarised in this guide examined single ingredients. No published study has tested this product or this combination of ingredients.
RAD-140 (testolone)
There are no controlled trials of RAD-140 in healthy people, so its effects and risks at the amounts used outside research are unknown. Analyses of products sold online as SARMs found that many did not contain what the label stated, or contained other unapproved substances11.
LGD-4033 (ligandrol)
The human data come from short trials at low doses under medical supervision. There are no long-term safety or outcome data2. Analyses of products sold online as SARMs found that many did not contain the substance or amount stated on the label, and some contained other unapproved drugs11.
YK-11
No human efficacy or safety data exist.
MK-677 (ibutamoren)
The trials were in older adults under medical supervision. There are no controlled studies in healthy young people or athletes. Analyses of products sold online as SARMs found that many did not contain the substance or amount stated on the label, and some contained other unapproved drugs11.
Prohormones and designer anabolic steroids
Products are often mislabelled or adulterated, so the actual steroid and dose are uncertain1213.
Plant "anabolic" sterols (laxogenin, ecdysterone)
Label accuracy is poor and human trials are few9.
Safety & potential risks
Independent researchRAD-140 (testolone)
Case reports describe drug-induced liver injury, including jaundice, in people using products containing RAD-14014. A national case series linked SARMs and other bodybuilding products to drug-induced liver injury15.
A systematic review of SARM use by athletes reports liver toxicity, heart toxicity, tendon damage, suppression of natural testosterone and other androgenic effects16.
LGD-4033 (ligandrol)
Cholestatic liver injury, confirmed by biopsy, has been reported in a person using ligandrol17. A systematic review of SARM use by athletes reports liver toxicity, heart toxicity, tendon damage, suppression of natural testosterone and other androgenic effects16. A national case series linked SARMs and other bodybuilding products to drug-induced liver injury15.
YK-11
Human safety is unknown. A systematic review of SARM use by athletes reports liver toxicity, heart toxicity, tendon damage, suppression of natural testosterone and other androgenic effects16. A national case series linked SARMs and other bodybuilding products to drug-induced liver injury15.
MK-677 (ibutamoren)
Reported effects in trials include increased appetite, fluid retention and raised blood glucose; heart failure occurred in a small number of frail older patients48.
Prohormones and designer anabolic steroids
Case reports describe drug-induced liver injury, including cholestasis, from prohormone and bodybuilding supplements containing anabolic-androgenic steroids121315. Anabolic steroids also suppress natural testosterone production and adversely affect blood lipids and the heart.
Plant "anabolic" sterols (laxogenin, ecdysterone)
Human safety data are limited.
Regulatory status
Contains a selective androgen receptor modulator (SARM). SARMs are investigational substances that are not authorised as medicinal products or as food (including food supplements) in the EU and are on the World Anti-Doping Agency (WADA) Prohibited List. Contains an investigational growth-hormone secretagogue. It is not authorised as a medicinal product or as food (including food supplements) in the EU and is on the WADA Prohibited List. Contains synthetic anabolic-androgenic steroid compounds or prohormones. These are not authorised as food (including food supplements) or as medicinal products in the EU and are on the WADA Prohibited List. No dosing information for human use is provided.
RAD-140 (testolone)
RAD-140 is not an approved medicine and is not permitted in food or food supplements in the EU1819. SARMs have been on the World Anti-Doping Agency Prohibited List since 2008 and are prohibited at all times2021.
LGD-4033 (ligandrol)
LGD-4033 is not an approved medicine and is not permitted in food or food supplements in the EU1819. SARMs have been on the World Anti-Doping Agency Prohibited List since 2008 and are prohibited at all times2021.
YK-11
YK-11 is not an approved medicine and is not permitted in food or food supplements in the EU1819. SARMs have been on the World Anti-Doping Agency Prohibited List since 2008 and are prohibited at all times2021.
MK-677 (ibutamoren)
MK-677 is not an approved medicine and is not permitted in food or food supplements in the EU1819. Growth hormone secretagogues are prohibited at all times by the World Anti-Doping Agency21.
Scientific references
- Miller CP, Shomali M, Lyttle CR, et al. Design, synthesis, and preclinical characterization of the selective androgen receptor modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2:124-129. PubMed 24900290
- Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68:87-95. PubMed 22459616
- Kanno Y, Ota R, Someya K, et al. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression. Biol Pharm Bull. 2013;36:1460-1465. PubMed 23995658
- Nass R, Pezzoli SS, Oliveri MC, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149:601-611. PubMed 18981485
- LoRusso P, Hamilton E, Ma C, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer. 2022;22:67-77. PubMed 34565686
- Wen J, Syed B, Leapart J, et al. Selective androgen receptor modulators (SARMs) effects on physical performance: a systematic review of randomized control trials. Clin Endocrinol (Oxf). 2025;102:3-27. PubMed 39285652
- Dahleh MMM, Bortolotto VC, Boeira SP, et al. From gains to gaps? How selective androgen receptor modulator (SARM) YK11 impact hippocampal function: in silico, in vivo, and ex vivo perspectives. Chem Biol Interact. 2024;394:110971. PubMed 38521455
- Adunsky A, Chandler J, Heyden N, et al. MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. Arch Gerontol Geriatr. 2011;53:183-189. PubMed 21067829
- Dissemond J, Havers T, Held S, et al. How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study. J Int Soc Sports Nutr. 2025;22:2540408. PubMed 40781783
- Derwand D, Zierau O, Wolf CA, et al. Effects of the dietary supplement 5α-hydroxy-laxogenin in the orchiectomized rat model. Drug Test Anal. 2025;17:1743-1749. PubMed 40038867
- Van Wagoner RM, Eichner A, Bhasin S, et al. Chemical composition and labeling of substances marketed as selective androgen receptor modulators and sold via the internet. JAMA. 2017;318:2004-2010. PubMed 29183075
- Magee CD, Witte S, Kwok RM, Deuster PA. Mission compromised? Drug-induced liver injury from prohormone supplements containing anabolic-androgenic steroids in two deployed U.S. service members. Mil Med. 2016;181:e1169-e1171. PubMed 27612377
- Matusak M, Aljabban J, Wirtz M, et al. Cholestasis linked to bodybuilding supplements: exploring the risks of contamination. Case Reports Hepatol. 2024;2024:5112461. PubMed 38826497
- Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033). ACG Case Rep J. 2020;7:e00409. PubMed 33062783
- Nash E, Nicoll A, Batt N, et al. Drug-induced liver injury from selective androgen receptor modulators, anabolic-androgenic steroids and bodybuilding supplements in Australia. Aliment Pharmacol Ther. 2024;59:953-961. PubMed 38372012
- Vasireddi N, Hahamyan HA, Gould HP, et al. Athlete selective androgen receptor modulators abuse: a systematic review. Am J Sports Med. 2025;53:999-1009. PubMed 39755947
- Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (LGD-4033)-induced liver injury. ACG Case Rep J. 2020;7:e00370. PubMed 32637435
- Directive 2001/83/EC on the Community code relating to medicinal products for human use. Official Journal of the European Union. Source
- Regulation (EU) 2015/2283 on novel foods. Official Journal of the European Union. Source
- Thevis M, Schänzer W. Detection of SARMs in doping control analysis. Mol Cell Endocrinol. 2018;464:34-45. PubMed 28137616
- World Anti-Doping Agency. The Prohibited List (current edition). Source
Sources checked against PubMed, Crossref or the official publisher on 2026-11-04. Manufacturer information is taken from the product's own data and has not been independently tested.
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Core Labs LX GH PRO ULTRA 60 caps
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