Revange No Stress

Phenibut

Phenibut (β-phenyl-γ-aminobutyric acid) is a GABA-B receptor agonist, a central nervous system depressant used as a medicine in Russia¹.

Rhodiola rosea

Rhodiola rosea is a plant from cold regions whose root extract (standardised to rosavins and salidroside) is marketed as an adaptogen.

5-HTP (5-hydroxytryptophan)

5-HTP is the direct precursor of the neurotransmitter serotonin and is usually extracted from Griffonia simplicifolia seeds².

L-theanine

L-theanine is an amino acid found in tea leaves, often combined with caffeine.

Mucuna pruriens (velvet bean, L-DOPA)

Mucuna pruriens seeds naturally contain L-DOPA (levodopa), the precursor of dopamine and the main medicine for Parkinson's disease.

Grape seed extract (OPC)

Grape seed extract is rich in oligomeric proanthocyanidins (OPCs), polyphenolic antioxidants.

Piperine (black pepper extract, BioPerine®)

Piperine is the pungent alkaloid of black pepper, added to supplements as a "bioavailability enhancer".

Phenibut

There are no controlled trials in healthy people supporting its use as a supplement.

Rhodiola rosea

A 2025 meta-analysis concluded that Rhodiola supplementation can improve endurance performance and related biomarkers, although differences between studies call for cautious interpretation³.

5-HTP (5-hydroxytryptophan)

A review of controlled trials examined 5-HTP for depression; the evidence is limited and of mixed quality². There is no authorised EU claim for 5-HTP.

L-theanine

A meta-analysis of randomised trials in healthy people found that theanine with caffeine, and theanine alone, could benefit cognitive and mood outcomes⁴.

Mucuna pruriens (velvet bean, L-DOPA)

A 12-month randomised trial in untreated Parkinson's disease in sub-Saharan Africa found Mucuna pruriens could be a cost-effective alternative where commercial levodopa is not available⁵. There is no good evidence that it raises testosterone or improves mood or performance in healthy people.

Grape seed extract (OPC)

A meta-analysis of 16 randomised controlled trials examined the effect of grape seed extract on blood pressure⁶.

Piperine (black pepper extract, BioPerine®)

A 2026 review of 22 human pharmacokinetic studies found that reports of enhanced nutrient absorption come mainly from manufacturer-affiliated studies, and that independent trials did not confirm enhancement for curcumin or resveratrol at supplement doses⁷.

Phenibut

Its marketing as a nootropic supplement is not supported by evidence¹.

Rhodiola rosea

Studies are heterogeneous in extract and dose³.

5-HTP (5-hydroxytryptophan)

Most trials are small and old².

L-theanine

More research with realistic doses and in everyday settings is needed⁴.

Mucuna pruriens (velvet bean, L-DOPA)

The trial used standardised preparations under medical supervision; larger double-blind trials are needed⁵. Supplements rarely state their L-DOPA content.

Grape seed extract (OPC)

Trials are small and use different extracts and doses⁶.

Piperine (black pepper extract, BioPerine®)

Piperine raises blood levels of other compounds mainly by inhibiting drug-metabolising enzymes (CYP3A4, CYP2C9) and P-glycoprotein, not by improving absorption⁷.

Phenibut

A systematic review describes serious toxicity and withdrawal syndromes with phenibut, including agitation, delirium and reduced consciousness, often requiring hospital treatment⁸. Dependence can develop quickly.

Rhodiola rosea

Generally well tolerated; it may interact with antidepressants and blood-pressure or diabetes medicines.

5-HTP (5-hydroxytryptophan)

Safety concerns include serotonin syndrome when combined with antidepressants or other serotonergic substances, and historical reports of eosinophilia-myalgia syndrome linked to contaminated products². Do not combine with antidepressants, migraine triptans or tramadol.

L-theanine

Generally well tolerated at studied doses.

Mucuna pruriens (velvet bean, L-DOPA)

L-DOPA can cause nausea, low blood pressure, involuntary movements and psychiatric effects, and it interacts with MAO inhibitors, antipsychotics and Parkinson's medicines. People with heart disease, psychiatric conditions or melanoma history should not use it without medical advice.

Grape seed extract (OPC)

Generally well tolerated; it may add to the effect of blood-thinning medicines.

Piperine (black pepper extract, BioPerine®)

Because it inhibits drug-metabolising enzymes, piperine can raise blood levels of prescription medicines, including drugs with a narrow therapeutic index. People taking medication should ask a pharmacist first⁷.

Contains a synthetic research compound that is not authorised as food (novel food) or as a medicinal product in the EU. No dosing information for human use is provided.

Phenibut

Phenibut is not authorised as a food or food supplement ingredient in the EU⁹. Substances with a pharmacological action on the nervous system are regulated as medicinal products in the EU, and Phenibut is not an authorised medicine¹⁰.

Rhodiola rosea

No health claim is authorised¹¹.

5-HTP (5-hydroxytryptophan)

5-HTP is pharmacologically active; some EU Member States restrict it in food supplements or classify it as medicinal¹⁰. No health claim for this ingredient is authorised in the EU¹¹; botanical ingredients are sold under national food-supplement rules¹².

L-theanine

No health claim for this ingredient is authorised in the EU¹¹; botanical ingredients are sold under national food-supplement rules¹².

Mucuna pruriens (velvet bean, L-DOPA)

Because it contains levodopa, a medicinal substance, the classification of Mucuna pruriens products differs between EU Member States¹⁰. No health claim for this ingredient is authorised in the EU¹¹; botanical ingredients are sold under national food-supplement rules¹².

Grape seed extract (OPC)

No health claim for this ingredient is authorised in the EU¹¹; it is sold under national food-supplement rules¹².

Piperine (black pepper extract, BioPerine®)

No health claim for this ingredient is authorised in the EU¹¹; botanical ingredients are sold under national food-supplement rules¹².