Product guide · Under compliance review

Smart Brothers DIHEXA (PNB-0408) 30 caps

Specialised product from Smart Brothers, 30 capsules. This guide sets out what the manufacturer states about the composition of Smart Brothers DIHEXA (PNB-0408) 30 caps, what independent research says about its main ingredient, and the safety and regulatory points that apply. Its regulatory status is under compliance review. This guide is educational and does not recommend use.

Educational guide · Sources checked 4 November 2026 · 3 references

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Named ingredients: 1
Amounts stated: None
Status: Under compliance review
Evidence summaries: 1

Overview

Manufacturer information

Smart Brothers DIHEXA (PNB-0408) 30 caps contains DIHEXA. Each pack holds 30 capsules. The strength is not stated in the product data.

Ingredients & composition

Manufacturer information

Ingredient	Amount
DIHEXA	Not stated

The manufacturer does not state the amount of any ingredient. Without amounts, the research summarised in this guide cannot be related to this product's dose.

Scientific background

Independent research

Experimental nootropics (sunifiram, IDRA-21, dihexa, emoxypine)

Sunifiram, IDRA-21 (an AMPA receptor modulator) and dihexa are experimental compounds studied in laboratory and animal models of memory. Emoxypine (Mexidol) is an antioxidant drug used clinically in Russia.

Research evidence

Independent research

Experimental nootropics (sunifiram, IDRA-21, dihexa, emoxypine)

Research on sunifiram, IDRA-21 and dihexa is preclinical; there are no published controlled human trials. Emoxypine studies come mainly from Russian clinical literature in specific diseases.

Evidence limitations

Independent research

This product does not state all ingredient amounts, so the doses used in research cannot be compared with what one serving provides.

No published study has tested this specific product; the research summarised here concerns the ingredient itself.

Experimental nootropics (sunifiram, IDRA-21, dihexa, emoxypine)

Safety and effects in healthy humans are unknown.

Safety & potential risks

Independent research

Experimental nootropics (sunifiram, IDRA-21, dihexa, emoxypine)

Human safety data are lacking. Official medicines control laboratories in Europe and Australia have found illicit "smart drugs" sold as nootropic products and warn of their dangers¹.

Regulatory status

GIGACULT product information

Flagged for compliance review: this product is listed as a food supplement in our catalogue, but its EU status (food supplement, novel food or medicinal product) has not been verified. No benefits or health claims are made.

Regulation and sport

Experimental nootropics (sunifiram, IDRA-21, dihexa, emoxypine)

These compounds are not authorised as a food or food supplement ingredient in the EU². Substances with a pharmacological action on the nervous system are regulated as medicinal products in the EU, and none is an authorised medicine³.

Scientific references

Vanhee C, Deconinck E, George M, et al. The occurrence of illicit smart drugs or nootropics in Europe and Australia and their associated dangers: results from a market surveillance study by 12 official medicines control laboratories. J Xenobiot. 2025;15:88. PubMed 40558871
Regulation (EU) 2015/2283 on novel foods. Official Journal of the European Union. Source
Directive 2001/83/EC on the Community code relating to medicinal products for human use. Official Journal of the European Union. Source

Sources checked against PubMed, Crossref or the official publisher on 2026-11-04. Manufacturer information is taken from the product's own data and has not been independently tested.

The product