GeneTech Pharma Labs P.C.T RX Hardcore 90 caps

Arimistane (androsta-3,5-diene-7,17-dione)

Arimistane (androsta-3,5-diene-7,17-dione) is sold as an aromatase inhibitor, a substance that blocks the conversion of testosterone to oestrogen. It is also related to the breakdown of 7-oxo-DHEA¹.

Plant "anabolic" sterols (laxogenin, ecdysterone)

Laxogenin (5α-hydroxy-laxogenin) and ecdysteroids such as ecdysterone (20-hydroxyecdysone, from Ajuga turkestanica or Cyanotis) are plant sterols marketed as natural anabolic agents.

Tongkat ali (Eurycoma longifolia)

Tongkat ali (Eurycoma longifolia) is a Southeast Asian shrub whose root extract is marketed for male vitality².

Tribulus terrestris

Tribulus terrestris is a herb used in traditional medicine and marketed for libido and testosterone.

Mucuna pruriens (velvet bean, L-DOPA)

Mucuna pruriens seeds naturally contain L-DOPA (levodopa), the precursor of dopamine and the main medicine for Parkinson's disease.

Saw palmetto (Serenoa repens)

Saw palmetto (Serenoa repens) berry extract is used for urinary symptoms of benign prostatic enlargement; some extracts are licensed herbal medicines in Europe³.

Horny goat weed (Epimedium, icariin)

Horny goat weed (Epimedium species) contains icariin, which inhibits the enzyme PDE5 in laboratory studies, the same target as erectile-dysfunction medicines.

Arimistane (androsta-3,5-diene-7,17-dione)

Published research concerns anti-doping detection of arimistane and its metabolites¹. There are no controlled human trials of its effects or safety.

Plant "anabolic" sterols (laxogenin, ecdysterone)

In a 12-week randomised double-blind training study, a commercial ecdysterone product gave no additional benefit over training alone, and its actual content differed markedly from the label⁴. In castrated rats, 5α-hydroxy-laxogenin showed neither androgenic nor anabolic effects⁵.

Tongkat ali (Eurycoma longifolia)

A meta-analysis of clinical trials found that tongkat ali supplementation increased total testosterone in men, particularly in men with low testosterone, but concluded that more research is needed before clinical use².

Tribulus terrestris

A meta-analysis of randomised trials assessed tribulus for erectile dysfunction using the International Index of Erectile Function⁶. Evidence that tribulus raises testosterone or improves muscle gain in healthy men is lacking.

Mucuna pruriens (velvet bean, L-DOPA)

A 12-month randomised trial in untreated Parkinson's disease in sub-Saharan Africa found Mucuna pruriens could be a cost-effective alternative where commercial levodopa is not available⁷. There is no good evidence that it raises testosterone or improves mood or performance in healthy people.

Saw palmetto (Serenoa repens)

A systematic review of recent clinical studies found improvements in prostate symptom scores in several trials, more consistently with hexane-extracted preparations, with variable effects on urinary flow³.

Horny goat weed (Epimedium, icariin)

Evidence for benefits comes mainly from laboratory and animal studies; robust human trials are lacking.

Arimistane (androsta-3,5-diene-7,17-dione)

Effects in humans are not established.

Plant "anabolic" sterols (laxogenin, ecdysterone)

Label accuracy is poor and human trials are few⁴.

Tongkat ali (Eurycoma longifolia)

The trials are small, often industry-funded and use different extracts².

Tribulus terrestris

Trials are small and use different extracts.

Mucuna pruriens (velvet bean, L-DOPA)

The trial used standardised preparations under medical supervision; larger double-blind trials are needed⁷. Supplements rarely state their L-DOPA content.

Saw palmetto (Serenoa repens)

Extracts, doses and study designs vary widely, limiting comparison³. Results from licensed extracts do not apply to all supplements.

Horny goat weed (Epimedium, icariin)

Human evidence is limited.

Arimistane (androsta-3,5-diene-7,17-dione)

Blocking oestrogen production can affect bone, lipids and mood. Human safety data are lacking.

Plant "anabolic" sterols (laxogenin, ecdysterone)

Human safety data are limited.

Tongkat ali (Eurycoma longifolia)

Generally well tolerated in short trials; long-term safety is not established. People with hormone-sensitive conditions should ask a doctor first.

Tribulus terrestris

Long-term safety has not been established in controlled trials. People taking medication for diabetes, blood pressure or the heart should ask a doctor first.

Mucuna pruriens (velvet bean, L-DOPA)

L-DOPA can cause nausea, low blood pressure, involuntary movements and psychiatric effects, and it interacts with MAO inhibitors, antipsychotics and Parkinson's medicines. People with heart disease, psychiatric conditions or melanoma history should not use it without medical advice.

Saw palmetto (Serenoa repens)

Generally well tolerated. Urinary symptoms should be assessed by a doctor before self-treatment to rule out other causes.

Horny goat weed (Epimedium, icariin)

Case reports describe toxicity with severe muscle spasms and raised creatine kinase⁸, and new-onset psychosis in a person with Parkinson's disease⁹.

Contains arimistane (androsta-3,5-diene-7,17-dione), a designer aromatase-inhibiting compound that is not authorised as food (novel food) in the EU and is on the WADA Prohibited List. No dosing information for human use is provided.

Arimistane (androsta-3,5-diene-7,17-dione)

Aromatase inhibitors are prohibited at all times by the World Anti-Doping Agency¹¹⁰, and arimistane is not authorised as a food ingredient in the EU¹¹.

Plant "anabolic" sterols (laxogenin, ecdysterone)

These plant sterols are not authorised novel foods in the EU¹¹. Ecdysterone is on the World Anti-Doping Agency monitoring programme¹⁰.

Tongkat ali (Eurycoma longifolia)

No health claim for this ingredient is authorised in the EU¹²; botanical ingredients are sold under national food-supplement rules¹³.

Tribulus terrestris

No health claim for this ingredient is authorised in the EU¹²; botanical ingredients are sold under national food-supplement rules¹³.

Mucuna pruriens (velvet bean, L-DOPA)

Because it contains levodopa, a medicinal substance, the classification of Mucuna pruriens products differs between EU Member States¹⁴. No health claim for this ingredient is authorised in the EU¹²; botanical ingredients are sold under national food-supplement rules¹³.

Saw palmetto (Serenoa repens)

Some saw palmetto extracts are authorised as traditional or well-established herbal medicines; as a food supplement ingredient no health claim is authorised¹⁴¹².

Horny goat weed (Epimedium, icariin)

No health claim for this ingredient is authorised in the EU¹²; it is sold under national food-supplement rules¹³.