Product guide · Restricted substance
Smart Brothers RAD-140 (testolone) SARM 60 caps
Research compound from Smart Brothers, 60 capsules. This guide sets out what the manufacturer states about the composition of Smart Brothers RAD-140 (testolone) SARM 60 caps, what independent research says about its main ingredient, and the safety and regulatory points that apply. It contains substances that are not authorised as food or medicine in the EU. This guide is educational: it does not recommend use and gives no directions for use.
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- Evidence summaries
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Overview
Manufacturer informationSmart Brothers RAD-140 (testolone) SARM 60 caps contains RAD-140 (Testolone): 10 mg per capsule. Each pack holds 60 capsules.
The manufacturer states 10 mg of RAD-140 per capsule. RAD-140 is an investigational compound: it has not been approved as a medicine, and there is no established safe dose for humans1.
Ingredients & composition
Manufacturer information| Ingredient | Amount |
|---|---|
| RAD-140 (Testolone) | 10 mg per capsule |
Scientific background
Independent researchRAD-140 (testolone)
RAD-140 (testolone) is a selective androgen receptor modulator (SARM): a synthetic, non-steroidal compound designed to activate androgen receptors in muscle and bone while having less effect on other tissues. It was developed as an investigational drug2.
Research evidence
Independent researchRAD-140 (testolone)
Preclinical studies in animals showed anabolic effects on muscle2. The only published human trial is a phase 1 study in women with advanced, hormone-receptor-positive breast cancer, which assessed safety and dosing in that disease; it was not a study of muscle or performance in healthy people1.
A systematic review of randomised trials of SARMs in general found positive effects on physical performance and body composition in the trials reviewed, with moderate rates of mild to moderate adverse effects3.
Evidence limitations
Independent researchNo published study has tested this specific product; the research summarised here concerns the ingredient itself.
RAD-140 (testolone)
There are no controlled trials of RAD-140 in healthy people, so its effects and risks at the amounts used outside research are unknown. Analyses of products sold online as SARMs found that many did not contain what the label stated, or contained other unapproved substances4.
Safety & potential risks
Independent researchRAD-140 (testolone)
Case reports describe drug-induced liver injury, including jaundice, in people using products containing RAD-1405. A national case series linked SARMs and other bodybuilding products to drug-induced liver injury6.
A systematic review of SARM use by athletes reports liver toxicity, heart toxicity, tendon damage, suppression of natural testosterone and other androgenic effects7.
Regulatory status
Contains RAD-140 (testolone), a selective androgen receptor modulator (SARM). SARMs are investigational substances that are not authorised as medicinal products or as food (including food supplements) in the EU, and they are on the World Anti-Doping Agency (WADA) Prohibited List. No dosing information for human use is provided.
Scientific references
- LoRusso P, Hamilton E, Ma C, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer. 2022;22:67-77. PubMed 34565686
- Miller CP, Shomali M, Lyttle CR, et al. Design, synthesis, and preclinical characterization of the selective androgen receptor modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2:124-129. PubMed 24900290
- Wen J, Syed B, Leapart J, et al. Selective androgen receptor modulators (SARMs) effects on physical performance: a systematic review of randomized control trials. Clin Endocrinol (Oxf). 2025;102:3-27. PubMed 39285652
- Van Wagoner RM, Eichner A, Bhasin S, et al. Chemical composition and labeling of substances marketed as selective androgen receptor modulators and sold via the internet. JAMA. 2017;318:2004-2010. PubMed 29183075
- Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033). ACG Case Rep J. 2020;7:e00409. PubMed 33062783
- Nash E, Nicoll A, Batt N, et al. Drug-induced liver injury from selective androgen receptor modulators, anabolic-androgenic steroids and bodybuilding supplements in Australia. Aliment Pharmacol Ther. 2024;59:953-961. PubMed 38372012
- Vasireddi N, Hahamyan HA, Gould HP, et al. Athlete selective androgen receptor modulators abuse: a systematic review. Am J Sports Med. 2025;53:999-1009. PubMed 39755947
- Directive 2001/83/EC on the Community code relating to medicinal products for human use. Official Journal of the European Union. Source
- Regulation (EU) 2015/2283 on novel foods. Official Journal of the European Union. Source
- Thevis M, Schänzer W. Detection of SARMs in doping control analysis. Mol Cell Endocrinol. 2018;464:34-45. PubMed 28137616
- World Anti-Doping Agency. The Prohibited List (current edition). Source
Sources checked against PubMed, Crossref or the official publisher on 2026-11-04. Manufacturer information is taken from the product's own data and has not been independently tested.
The product
Smart Brothers RAD-140 (testolone) SARM 60 caps
€54,90